







| 2026 | Mouse | Mr. Murdaugh |
| 2025 | This Ordinary Thing | Self (voice) |
| 2024 | Thầy Trừ Tà | Father Conor |
| 2019 | The Lavender Scare | Dr. Franklin E. Kameny (voice) |
| 2016 | Must See TV: An All Star Tribute to James Burrows | Self |
| 2015 | Hurricane of Fun: The Making of Wet Hot | Self |
| 2012 | Vanya and Sonia and Masha and Spike | Vanya |
| 2010 | Sondheim! The Birthday Concert | Self - Host |
| The Perfect Host | Warwick Wilson | |
| 2009 | Forever Plaid | The Narrator |
| Stingray Sam | Narrator | |
| 2008 | Monty Python Conquers America | Self |
| 2006 | The Amazing Screw-On Head | Emperor Zombie (voice) |
| World's Greatest Stand Up: Volume One | self | |
| 2005 | Celebrity Mix | Self (archive footage) |
| 2004 | Frasier: Analyzing the Laughter | Niles Crane |
| Quỷ Đỏ | Abe Sapien (voice) (uncredited) | |
| 2003 | Behind the Couch: The Making of 'Frasier' | Self |
| Down with Love | Peter MacMannus | |
| The Shakespeare Sessions | — | |
| 2002 | Hành Tinh Châu Báu | Doctor Doppler (voice) |
| Full Frontal | Carl | |
| Laud Weiner | Laud Weiner | |
| 2001 | Osmosis Jones: Cảnh Sát Bạch Cầu | Drix (voice) |
| Wet Hot American Summer | Henry | |
| On the Edge | Barney (segment "Happy Birthday") | |
| Chain of Fools | Mr. Kerner | |
| 2000 | The Tangerine Bear: Home in Time for Christmas! | Bird (voice) |
| Isn't She Great | Michael Hastings | |
| 1999 | The Mating Habits of the Earthbound Human | The Narrator |
| Jackie's Back! | Perry (The Deaf Rehearsal Pianist) | |
| The Frasier Story | Self | |
| 1998 | Thế Giới Côn Trùng | Slim (voice) |
| 1996 | Star Trek: 30 Years and Beyond | Niles Crane |
| 1995 | Nixon | John Dean |
| The World of James Bond | Self | |
| 1994 | Wolf | Roy McCallister |
| 1993 | Gia Đình Addams 2 | Delivery Room Doctor |
| Không Ngủ Ở Seattle | Dennis Reed | |
| 1991 | The Fisher King | Lou Rosen |
| Little Man Tate | Garth Emmerick | |
| 1989 | Vampire's Kiss | Theater Guy |
| 1988 | The Appointments of Dennis Jennings | Businessman |
| Rocket Gibraltar | Monsieur Henri | |
| Crossing Delancey | Mark | |
| Bright Lights, Big City | Bartender at Fashion Show | |
| 1985 | Moving Violations | Immigration Officer |
| 2025 | Hold | Executive Producer |
| 2024 | Facing the Wind | Executive Producer |
| Visiting Birdie | Executive Producer | |
| 2020 | Sky Blossom | Executive Producer |
| 2010 | Sondheim! The Birthday Concert | Writer |