| 2028 | Captain Zero: The Movie | (voice) |
| 2025 | Leopardi & Co | Mildred |
| ASALI: Power of the Pollinators | Galbanum (voice) |
| Flower of the Dawn | Storyteller (voice) |
| 2024 | Thom Browne: The Man Who Tailors Dreams | self |
| Like Tears in Rain | Self |
| Super/Man: Câu chuyện của Christopher Reeve | Self |
| Atrabilious | Dr. Andrea Hart |
| Group Therapy | Self (archive footage) |
| Ezra | Jayne |
| Butterfly in the Sky | Self |
| Babes | Dawn's Breasts |
| Outlaw Posse | Stagecoach Mary |
| I'm "George Lucas": A Connor Ratliff Story | Self (archive footage) |
| 2023 | Oprah & The Color Purple Journey | Self |
| Màu Tím | Midwife (uncredited) |
| Three Trees | (Narration) |
| Barry Humphries at the BBC | Self (archive material) |
| Commitment to Life | Self (archive footage) |
| Our Barbara | Self |
| 2022 | My Father's Dragon | Cat (voice) |
| 20/20 Presents Black Panther: In Search of Wakanda | Self |
| Till | Alma |
| Music Is My Life: Joseph Shabalala and Ladysmith Black Mambazo | Self |
| Is That Black Enough for You?!? | Self |
| Cinderella: The Reunion, A Special Edition of 20/20 | Self |
| Thời Vận - Luck | Captain (voice) |
| Tony Bennett: Forget Me Not | Self |
| Bill Cosby: Walking Free | Self (archive footage) |
| Whoopi Goldberg: The Winning Act | Self (archive footage) |
| Soul of a Nation Presents: Screen Queens Rising | Self |
| 2021 | JFK Revisited: Through the Looking Glass | Self - Narrator (voice) |
| The Most Magical Story on Earth: 50 Years of Walt Disney World | Self - Host |
| Rita Moreno: Just a Girl Who Decided to Go for It | Self |
| Sesame Street: 50 Years of Sunny Days | Self - Guest |
| 2020 | Billy Connolly: It’s Been a Pleasure... | Self |
| Sarah Cooper: Everything's Fine | Whoopi Goldberg (voice) |
| Walter Winchell: The Power of Gossip | Narrator |
| The Great Work Begins: Scenes from Angels in America | Whoopi Goldberg |
| A Virtual Princess Bride Reunion | The Mother / The Ancient Booer |
| Chadwick Boseman: A Tribute for a King | Self - Co-host, "The View" |
| Feeding America Comedy Festival | Self |
| My Darling Vivian | Self (archive footage) |
| Celebrating 25 Magical Years of Disney on Broadway | — |
| The Sit-In: Harry Belafonte Hosts The Tonight Show | Self |
| Find Your Groove | Self |
| The Paley Center Salutes Law & Order: SVU | (archive footage) |
| 2019 | Sesame Street's 50th Anniversary Celebration | Self |
| The Most Magnificent Thing | Narrator (voice) |
| Cracked Up | Self |
| Charley Pride: I'm Just Me | Self |
| 2018 | Olympia | Self |
| Gạo Nếp Gạo Tẻ | Lola |
| Trump @War | Self (archive footage) |
| Scotty and the Secret History of Hollywood | Self (archive footage) |
| The Gospel According to André | Self |
| Furlough | Moms |
| Mister Rogers: It's You I Like | Self |
| 2017 | Decorating Disney: Holiday Magic | Host |
| The Problem with Apu | Self |
| Sammy Davis, Jr.: I've Gotta Be Me | Self |
| Yamasong: March of the Hollows | Yari (voice) |
| 9/11 | Metzie |
| Hậu Duệ 2 | Ursula (voice) (uncredited) |
| The Truth Is in the Stars | Self |
| Gilbert | Self |
| A Very Sordid Wedding | Abernatha Coleman |
| King of the Dancehall | Loretta Brixton |
| Rio | Gayle Morgenstern |
| 2016 | X-Rated 2: The Greatest Adult Stars of All-Time | Self |
| Do I Look Like a Lady? (Comedians and Singers) | Self (archive footage) |
| The Beatles: Eight Days a Week - The Touring Years | Self |
| 50 Years of Star Trek | Self |
| Floyd Norman: An Animated Life | Herself |
| 2015 | Black Dog, Red Dog | Calliope |
| The Three Stooges: Hey Moe! Hey Dad! | Self |
| De magie van het dagboek van Anne Frank | Self |
| Misery Loves Comedy | Self |
| 2014 | Top Five | Whoopi Goldberg |
| Big Stone Gap | Fleeta Mullins |
| Ninja Rùa | Bernadette Thompson |
| A Day Late and a Dollar Short | Viola |
| 2013 | Kelly Clarkson's Cautionary Christmas Music Tale | Self |
| Star Trek: The Next Generation - Redemption | Guinan |
| Cá đen | Self |
| Star Trek: The Next Generation - The Best of Both Worlds | Guinan (archive footage) |
| Richard Pryor: Omit the Logic | Self |
| Whoopi Goldberg Presents Moms Mabley | Self |
| Why We Laugh: Funny Women | Self |
| Miracle Rising: South Africa | Self |
| The Contradictions of Fair Hope | Narrator |
| 2012 | 12-12-12 | The Concert for Sandy Relief | Self |
| Radioman | Self |
| Katy Perry: Part of Me | Self |
| Paul Simon: Under African Skies | Self |
| Python Legs! | — |
| 2011 | Đại Nhạc Hội Rối | Whoopi Goldberg |
| Being Elmo: A Puppeteer's Journey | Narrator (voice) |
| The Little Engine That Could | The Tower (voice) |
| A Little Bit of Heaven | God |
| 2010 | Cho Những Cô Gái Da Màu | Alice / White |
| Teenage Paparazzo | Self |
| 2Everything2Terrible2: Tokyo Drift | (archive footage) |
| New York Street Games | Self |
| Câu Chuyện Đồ Chơi 3 | Stretch (voice) |
| The Black List: Volume Three | Self |
| See You in September | Lindsay's Therapist (uncredited) |
| 2009 | Square Roots: The Story of SpongeBob SquarePants | Self (archive footage) |
| Journey to the Stars | Narrator (voice) |
| कमबख़्त इश्क़ | Whoopi Goldberg |
| Star Trek: The Captain's Summit | Self |
| Madea Đi Tù | Self |
| Stream | Jodi Quinn |
| 2008 | A Muppets Christmas: Letters to Santa | Taxi Driver |
| Descendants | Red Flower (voice) |
| Meerkat Manor: The Story Begins | Self - Narrator (voice) |
| Snow Buddies | Miss Mittens (voice) |
| Comic Relief: The Greatest... and the Latest | — |
| 2007 | Nuremberg: The 60th Anniversary Director's Cut | Self |
| Mr. Warmth: The Don Rickles Project | Self |
| Annie Leibovitz: Life Through a Lens | Self |
| The Sophisticated Misfit | Self |
| Elton 60: Live At Madison Square Garden | Self |
| Ghost Stories: The Making of a Classic | Self |
| If I Had Known I Was a Genius | Mom |
| 2006 | Farce of the Penguins | Helen (voz) |
| Comic Relief 2006 | — |
| Homie Spumoni | Thelma |
| Everyone's Hero | Darlin' (voice) |
| Doogal | Ermintrude (voice) |
| The N Word | Self |
| 2005 | The Aristocrats | Self |
| Jiminy Glick in Lalawood | Whoopi Goldberg |
| Whoopi Goldberg: Back to Broadway | Herself / Fontaine / Lurleen / Crippled Lady |
| Racing Stripes | Franny (voice) |
| 2004 | Vua Sư Tử 3 | Shenzi (voice) |
| Superbabies: Baby Geniuses 2 | Whoopi Goldberg |
| The World of Nat King Cole | Self |
| Pinocchio 3000 | Cyberina (voice) |
| Uta Hagen's Acting Class | Self |
| TV in Black: The First Fifty Years | Self (archive footage) |
| 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self |
| New Jersey Devils Stanley Cup 2002-2003 Champions | Voice |
| Declaration of Independence | Self |
| Blizzard | Blizzard (voice) |
| Pauly Shore Is Dead | Whoopi Goldberg |
| Unchained Memories: Readings from the Slave Narratives | Narrator (voice) |
| Good Fences | Mabel Spader |
| 2002 | Star Trek: Nemesis | Guinan (uncredited) |
| It's a Very Merry Muppet Christmas Movie | Daniel's 'Boss' |
| Madeline: My Fair Madeline | Miss Clavel (voice) |
| The Hollywood Sign | Woman at Funeral (uncredited) |
| Searching for Debra Winger | Self |
| Showboy | Herself |
| Making Rat Race | Herself |
| 2001 | The Making of 'A Charlie Brown Christmas' | Self - Hostess |
| Call Me Claus | Lucy Cullins |
| Cuộc Đua Cam Go | Vera Baker |
| Rescued from the Closet | Self |
| Ghost: Remembering the Magic | Self |
| Kingdom Come | Raynelle Slocumb |
| Monkeybone | Death |
| Golden Dreams | Califia, the Queen of California |
| What Makes a Family | Terry Harrison |
| 2000 | Chuck Jones: Extremes and In-Betweens - A Life in Animation | Self |
| Mary Pickford: A Life on Film | Self - Host / Narrator |
| More Dogs Than Bones | Cléo |
| The Adventures of Rocky & Bullwinkle | Judge Cameo (uncredited) |
| Here's to You, Charlie Brown: 50 Great Years | Self - Host |
| 1999 | Gián Đoạn | Valerie |
| Jackie's Back! | Nurse Ethyl Washington Rue Owens (Jackie's Sister) |
| The Deep End of the Ocean | Candy Bliss |
| Alice in Wonderland | Cheshire Cat |
| Our Friend, Martin | Mrs. Peck (voice) |
| Alegría | Baby Clown |
| Get Bruce! | Self |
| Billy Connolly: Erect for 30 Years | — |
| 1998 | The Rugrats Movie | Ranger Margaret (voice) |
| A Knight in Camelot | Dr. Vivien Morgan |
| Rudolph the Red-Nosed Reindeer: The Movie | Stormella (voice) |
| Junket Whore | Self |
| How Stella Got Her Groove Back | Delilah Abraham |
| 成龍的傳奇 | Self (uncredited) |
| Titey | The Iceberg (voice) |
| An Alan Smithee Film: Burn, Hollywood, Burn | Whoopi Goldberg |
| Creating Ragtime | Host |
| 1997 | A Christmas Carol | Spirit of Christmas Present (voice) |
| Cinderella | Queen Constantina |
| Mother Goose: A Rappin' and Rhymin' Special | Mother Gooseberg (voice) |
| In & Out | Whoopi Goldberg |
| Pitch | Self |
| Destination Anywhere | Cabbie |
| In the Gloaming | Nurse Myrna |
| Sports on the Silver Screen | Self (archive footage) |
| Happy Birthday Elizabeth: A Celebration of Life | Self |
| 1996 | Ghosts of Mississippi | Myrlie Evers |
| The Associate | Laurel Ayres |
| Bogus | Harriet Franklin |
| Bordello of Blood | Hospital Patient (uncredited) |
| The Sunshine Boys | Nurse (uncredited) |
| Eddie | Eddie Franklin |
| The Celluloid Closet | Self |
| 1995 | Theodore Rex | Katie Coltrane |
| The Rolling Stones: Voodoo Lounge | Self - Hostess |
| Moonlight and Valentino | Sylvie Morrow |
| The Rolling Stones - Voodoo Lounge Uncut | Self - Host |
| Bonnie Raitt Has Something To Talk About | Self |
| Boys on the Side | Jane Deluca |
| 1994 | The Making of 'The Pagemaster' | Self (archive footage) |
| The Pagemaster | Fantasy (voice) |
| Star Trek: Các Thế Hệ | Guinan (uncredited) |
| Corrina, Corrina | Corrina Washington |
| Bọn Trẻ Ranh | Buckwheat's Mom |
| Vua Sư Tử | Shenzi (voice) |
| But... Seriously | Self (archive footage) |
| Liberation | Narrator |
| Sesame Street: The Best of Elmo | Self |
| 1993 | A Cool Like That Christmas | Mom / Irwin (voice) |
| Sister Act 2: Back in the Habit | Deloris Van Cartier |
| Naked in New York | Tragedy Mask on Theater Wall |
| Sesame Street Jam: A Musical Celebration | Self (segment "Monster in the Mirror") |
| Aretha Franklin: Duets | Self |
| National Lampoon's Loaded Weapon 1 | Billy York (uncredited) |
| Made in America | Sarah Mathews |
| 1992 | The Magical World of Chuck Jones | Self |
| Sarafina! | Mary Masembuko |
| Metallica: A Year and a Half in the Life of Metallica | Self |
| Wisecracks | — |
| Sister Act | Deloris Van Cartier / Sister Mary Clarence |
| The Player | Detective Avery |
| Defenders of Dynatron City | Ms. Megawatt (voice) |
| 1991 | House Party 2 | Professor (uncredited) |
| Star Trek: 25th Anniversary Special | Self |
| Rabbit Ears - Koi and the Kola Nuts | Narrator (voice) |
| Chez Whoopi | Self - Host |
| Soapdish | Rose Schwartz |
| 1990 | The Long Walk Home | Odessa Cotter |
| Red Hot + Blue: A Tribute to Cole Porter | Self (uncredited) |
| Hồn Ma | Oda Mae Brown |
| Comic Relief '90 | Self |
| Celebrity Guide to Wine | Self |
| Help Save Planet Earth | Self |
| 1989 | Beverly Hills Brats | Self |
| Whoopi Goldberg Presents: Billy Connolly | Herself |
| Homer and Eddie | Eddie Cervi |
| Hanna-Barbera's 50th | Self |
| Kiss Shot | Sarah Collins |
| Comic Relief III | — |
| 1988 | Pee-wee's Playhouse Christmas Special | Self |
| Free to Be... a Family | Self |
| Clara's Heart | Clara Mayfield |
| Whoopi Goldberg's Fontaine... Why Am I Straight? | Fontaine |
| Nelson Mandela 70th Birthday Tribute | Self |
| The Telephone | Vashti Blue |
| The Nelson Mandela 70th Birthday Concert | Self |
| 1987 | Fatal Beauty | Rita Rizzoli |
| Funny, You Don't Look 200: A Constitutional Vaudeville | Lu Lu - Constitutional Caterer |
| Happy 100th Birthday, Hollywood | Self |
| Scared Straight!: 10 Years Later | Self - Host |
| Burglar | Bernice 'Bernie' Rhodenbarr |
| Carol, Carl, Whoopi and Robin | Self |
| The Pointer Sisters: Up All Nite | Self |
| Citizen Steve | Self - Actress |
| Repairs | The Voice (voice) |
| 1986 | The Best of Comic Relief | Self |
| Jumpin' Jack Flash | Terry Dolittle |
| The Making of Captain EO | Self |
| Bob Goldthwait: Don't Watch This Show | Self |
| Doctor Duck's Super Secret All-Purpose Sauce | Self |
| 1985 | Màu Tím | Celie |
| Whoopi Goldberg: Direct from Broadway | Self |
| Night of 100 Stars II | Self |
| 1982 | Citizen | — |